Endocrine Abstracts

Objective: The primary objective was to characterise the paracrine milieu in three subjects with apparently idiopathic gigantomastia and to study the relative expression of implicated factors in these pathological specimens as compared to tissue samples from normal breast, gynecomastia and breast cancer.Background: Gigantomastia refers to pathological breast enlargement usually occurring in the peripubertal or peripartum period. Idiopathic gigantomastia,...

Objective: To study O6-methylguanine-DNA methyltransferase (MGMT) immunoexpression to access the efficacy of Temozolamide (TMZ) as a part of multimodality treatment.Background: Aggressive or residual pituitary tumours are associated with substantial morbidity. Treatment options are often limited, and chemotherapy are associated with dismal results. Recent reports have documented the efficacy of TMZ therapy in aggressive pituitary tumors resistant to mult...